Assay Detail
Binding
CHEMBL752506
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition by displacing [3H]-Glycine of N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 1 (CHEMBL330) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazoline-2-carboxylates as novel excitatory amino acid antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.53 | 7.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274588 | — | — | 1 | 7.13 |
| CHEMBL8693 | — | — | 1 | 6.72 |
| CHEMBL8829 | — | — | 1 | 5.09 |
| CHEMBL267276 | TQX-173 | — | 1 | 4.47 |
| CHEMBL267006 | — | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274588 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL8693 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL8829 | — | Ki | = | 8200.0 | nM | 5.09 |
| CHEMBL267276 | TQX-173 | Ki | = | 33500.0 | nM | 4.47 |
| CHEMBL267006 | — | Ki | = | 57000.0 | nM | 4.24 |