Assay Detail
Binding
CHEMBL752535
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Inhibitory concentration required for in vitro binding affinity to Nicotinic acetylcholine receptor alpha3-beta2 expressed on cell line sf 9 by using [3H]-MCC
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha3/beta2 (CHEMBL2109234) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Identification of novel (isoxazole)methylene-1-azabicyclic compounds with high affinity for the central nicotinic cholinergic receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.41 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58416 | — | — | 1 | 8.72 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 8.42 |
| CHEMBL291442 | — | — | 1 | 7.85 |
| CHEMBL274525 | ABT-418 | — | 1 | 7.21 |
| CHEMBL144540 | — | — | 1 | 6.93 |
| CHEMBL60656 | — | — | 1 | 6.66 |
| CHEMBL293142 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58416 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL3 | NICOTINE | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL291442 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL274525 | ABT-418 | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL144540 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL60656 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL293142 | — | IC50 | = | 854.0 | nM | 6.07 |