Assay Detail
Binding
CHEMBL752536
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Binding affinity towards alpha3-beta4 subtype of neuronal nicotinic acetylcholine receptor (nAChR) using [3H]epibatidine as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha3/beta2 (CHEMBL2109234) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis and nicotinic binding of novel phenyl derivatives of UB-165. Identifying factors associated with alpha7 selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.02 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1086655 | — | — | 1 | 8.19 |
| CHEMBL444572 | — | — | 1 | 7.65 |
| CHEMBL329084 | — | — | 1 | 7.25 |
| CHEMBL96828 | — | — | 1 | 6.33 |
| CHEMBL93983 | — | — | 1 | 5.70 |
| CHEMBL419700 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1086655 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL444572 | — | Ki | = | 22.5 | nM | 7.65 |
| CHEMBL329084 | — | Ki | = | 56.3 | nM | 7.25 |
| CHEMBL96828 | — | Ki | = | 468.0 | nM | 6.33 |
| CHEMBL93983 | — | Ki | = | 1990.0 | nM | 5.70 |
| CHEMBL419700 | — | Ki | > | 50000.0 | nM | - |