Assay Detail
Binding
CHEMBL752567
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cells
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor; GRIN1/GRIN2B (CHEMBL1907603) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.62 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416690 | — | — | 1 | 9.40 |
| CHEMBL65693 | — | — | 1 | 9.17 |
| CHEMBL65454 | — | — | 1 | 9.09 |
| CHEMBL68134 | — | — | 1 | 9.07 |
| CHEMBL436521 | — | — | 1 | 9.00 |
| CHEMBL64941 | — | — | 1 | 8.96 |
| CHEMBL65231 | — | — | 1 | 8.82 |
| CHEMBL65314 | — | — | 1 | 8.52 |
| CHEMBL63200 | — | — | 1 | 8.49 |
| CHEMBL303832 | — | — | 1 | 8.38 |
| CHEMBL304274 | — | — | 1 | 7.82 |
| CHEMBL66539 | — | — | 1 | 7.77 |
| CHEMBL63992 | — | — | 1 | 7.68 |
| CHEMBL65245 | — | — | 1 | 7.03 |
| CHEMBL63924 | — | — | 1 | 6.85 |
| CHEMBL65119 | — | — | 1 | 6.75 |
| CHEMBL65039 | — | — | 1 | 6.62 |
| CHEMBL67249 | — | — | 1 | 6.58 |
| CHEMBL304070 | — | — | 1 | 6.38 |
| CHEMBL61895 | — | — | 1 | 6.33 |
| CHEMBL63474 | — | — | 1 | 6.10 |
| CHEMBL63146 | — | — | 1 | 5.27 |
| CHEMBL67196 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416690 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL65693 | — | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL65454 | — | Ki | = | 0.82 | nM | 9.09 |
| CHEMBL68134 | — | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL436521 | — | Ki | = | 0.99 | nM | 9.00 |
| CHEMBL64941 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL65231 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL65314 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL63200 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL303832 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL304274 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL66539 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL63992 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL65245 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL63924 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL65119 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL65039 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL67249 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL304070 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL61895 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL63474 | — | Ki | = | 790.0 | nM | 6.10 |
| CHEMBL63146 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL67196 | — | Ki | = | 8400.0 | nM | 5.08 |