Assay Detail
Binding
CHEMBL752609
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Binding affinity against Opioid receptor delta 1 in guinea pig brain homogenate using [3H]- DPDPE as radioligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of highly potent and selective cyclic dynorphin A analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.11 | 8.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385759 | — | — | 1 | 8.79 |
| CHEMBL411557 | DYNORPHIN A (1-17) | — | 1 | 8.60 |
| CHEMBL443068 | — | — | 1 | 8.40 |
| CHEMBL415330 | — | — | 1 | 8.39 |
| CHEMBL216640 | — | — | 1 | 8.16 |
| CHEMBL410616 | — | — | 1 | 7.84 |
| CHEMBL265824 | — | — | 1 | 7.73 |
| CHEMBL384250 | — | — | 1 | 6.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385759 | — | IC50 | = | 1.63 | nM | 8.79 |
| CHEMBL411557 | DYNORPHIN A (1-17) | IC50 | = | 2.54 | nM | 8.60 |
| CHEMBL443068 | — | IC50 | = | 3.97 | nM | 8.40 |
| CHEMBL415330 | — | IC50 | = | 4.07 | nM | 8.39 |
| CHEMBL216640 | — | IC50 | = | 6.99 | nM | 8.16 |
| CHEMBL410616 | — | IC50 | = | 14.3 | nM | 7.84 |
| CHEMBL265824 | — | IC50 | = | 18.6 | nM | 7.73 |
| CHEMBL384250 | — | IC50 | = | 104.0 | nM | 6.98 |