Assay Detail
Binding
CHEMBL752610
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against delta opioid receptor of Guinea pig brain homogenate using [3H]c[D-Pen2,p-Cl-Phe4,D-Pen5]enkephalin
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis using a Fmoc-based strategy and biological activities of some reduced peptide bond pseudopeptide analogues of dynorphin A1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.24 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2370496 | — | — | 1 | 7.89 |
| CHEMBL2370494 | — | — | 1 | 7.77 |
| CHEMBL2370495 | — | — | 1 | 7.75 |
| CHEMBL2311023 | — | — | 1 | 7.62 |
| CHEMBL216640 | — | — | 1 | 7.58 |
| CHEMBL2311025 | — | — | 1 | 7.50 |
| CHEMBL2370497 | — | — | 1 | 7.28 |
| CHEMBL2311024 | — | — | 1 | 6.70 |
| CHEMBL2311022 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2370496 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2370494 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2370495 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2311023 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL216640 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2311025 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2370497 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL2311024 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL2311022 | — | IC50 | = | 7997.0 | nM | 5.10 |