Assay Detail
Binding
CHEMBL752656
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Activation potency at Nicotinic acetylcholine receptor alpha3beta4, expressed as concentration required to achieve a half maximal activation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha3/beta4 (CHEMBL1907593) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.10 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | — | 1 | 7.85 |
| CHEMBL63102 | — | — | 1 | 6.51 |
| CHEMBL274538 | — | — | 1 | 5.80 |
| CHEMBL25619 | — | — | 1 | 5.64 |
| CHEMBL10886 | — | — | 1 | 5.41 |
| CHEMBL111008 | — | — | 1 | 5.38 |
| CHEMBL327104 | — | — | 1 | - |
| CHEMBL323045 | — | — | 1 | - |
| CHEMBL10863 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL63102 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL274538 | — | EC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL25619 | — | EC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL10886 | — | EC50 | = | 3890.0 | nM | 5.41 |
| CHEMBL111008 | — | EC50 | = | 4190.0 | nM | 5.38 |
| CHEMBL327104 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL323045 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL10863 | — | EC50 | > | 100000.0 | nM | - |