Assay Detail
Functional
CHEMBL752657
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha3-beta4 expressed in Xenopus oocytes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Oocyte |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha3/beta4 (CHEMBL1907593) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Epibatidine structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.35 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | — | 1 | 6.89 |
| CHEMBL301901 | — | — | 1 | 6.72 |
| CHEMBL56682 | — | — | 1 | 6.50 |
| CHEMBL56817 | DESCHLOROEPIBATIDINE | — | 1 | 6.15 |
| CHEMBL56358 | — | — | 1 | 5.49 |
| CHEMBL667 | ACETYLCHOLINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL301901 | — | EC50 | = | 189.0 | nM | 6.72 |
| CHEMBL56682 | — | EC50 | = | 319.0 | nM | 6.50 |
| CHEMBL56817 | DESCHLOROEPIBATIDINE | EC50 | = | 702.0 | nM | 6.15 |
| CHEMBL56358 | — | EC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL667 | ACETYLCHOLINE | EC50 | = | 217000.0 | nM | - |