Assay Detail
Binding
CHEMBL752658
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Binding affinity at rat brain Nicotinic acetylcholine receptor alpha3-beta4
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha3/beta4 (CHEMBL1907593) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.87 | 10.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | — | 1 | 10.11 |
| CHEMBL63102 | — | — | 1 | 8.19 |
| CHEMBL274538 | — | — | 1 | 7.65 |
| CHEMBL25619 | — | — | 1 | 7.59 |
| CHEMBL10886 | — | — | 1 | 6.63 |
| CHEMBL111008 | — | — | 1 | 6.51 |
| CHEMBL10863 | — | — | 1 | 5.55 |
| CHEMBL327104 | — | — | 1 | 4.98 |
| CHEMBL323045 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | Ki | = | 0.077 | nM | 10.11 |
| CHEMBL63102 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL274538 | — | Ki | = | 22.5 | nM | 7.65 |
| CHEMBL25619 | — | Ki | = | 25.4 | nM | 7.59 |
| CHEMBL10886 | — | Ki | = | 236.0 | nM | 6.63 |
| CHEMBL111008 | — | Ki | = | 306.0 | nM | 6.51 |
| CHEMBL10863 | — | Ki | = | 2846.0 | nM | 5.55 |
| CHEMBL327104 | — | Ki | = | 10500.0 | nM | 4.98 |
| CHEMBL323045 | — | Ki | = | 22000.0 | nM | 4.66 |