Assay Detail
Binding
CHEMBL752669
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Binding affinity for human nociceptin (NOP) receptor using [3H]N/OFQ as radioligand transfected into CHO cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The design and synthesis of a novel quinolizidine template for potent opioid and opioid receptor-like (ORL1, NOP) receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.77 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396460 | NOCICEPTIN | — | 1 | 10.22 |
| CHEMBL53256 | — | — | 1 | 9.31 |
| CHEMBL51972 | — | — | 1 | 8.24 |
| CHEMBL52604 | — | — | 1 | 7.71 |
| CHEMBL54735 | — | — | 1 | 7.54 |
| CHEMBL54603 | — | — | 1 | 6.72 |
| CHEMBL299660 | — | — | 1 | 6.27 |
| CHEMBL291901 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396460 | NOCICEPTIN | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL53256 | — | Ki | = | 0.49 | nM | 9.31 |
| CHEMBL51972 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL52604 | — | Ki | = | 19.6 | nM | 7.71 |
| CHEMBL54735 | — | Ki | = | 28.7 | nM | 7.54 |
| CHEMBL54603 | — | Ki | = | 189.0 | nM | 6.72 |
| CHEMBL299660 | — | Ki | = | 535.0 | nM | 6.27 |
| CHEMBL291901 | — | Ki | = | 786.0 | nM | 6.11 |