Assay Detail
Binding
CHEMBL752866
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for its affinity towards N-methyl-D-aspartate glutamate receptor in male Swiss Webster mice.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of 8a-phenyldecahydroquinolines as probes of PCP's binding conformation. A new PCP-like compound with increased in vivo potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.55 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284237 | DIZOCILPINE | 2.0 | 1 | 8.85 |
| CHEMBL275528 | PHENCYCLIDINE | 2.0 | 1 | 7.46 |
| CHEMBL290048 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284237 | DIZOCILPINE | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL275528 | PHENCYCLIDINE | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL290048 | — | IC50 | = | 467.4 | nM | 6.33 |