Assay Detail
Binding
CHEMBL752872
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Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 with a Y181C mutation in RT (reverse transcriptase)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Anti-HIV activity of aromatic and heterocyclic thiazolyl thiourea compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.06 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116474 | — | — | 1 | 7.32 |
| CHEMBL144604 | — | — | 1 | 7.16 |
| CHEMBL149161 | — | — | 1 | 6.22 |
| CHEMBL146770 | — | — | 1 | 6.05 |
| CHEMBL148698 | — | — | 1 | 5.70 |
| CHEMBL151773 | — | — | 1 | 5.68 |
| CHEMBL356247 | — | — | 1 | 5.66 |
| CHEMBL149100 | — | — | 1 | 5.41 |
| CHEMBL345996 | — | — | 1 | 5.36 |
| CHEMBL358280 | — | — | 1 | - |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116474 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL144604 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL149161 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL146770 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL148698 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL151773 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL356247 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL149100 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL345996 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL358280 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL57 | NEVIRAPINE | IC50 | > | 100000.0 | nM | - |