Assay Detail
Binding
CHEMBL752896
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for opioid receptor type, human Opioid receptor delta 1 expressed in membrane homogenates of COS-1 or CHO cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | COS-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Probing opioid receptor interactions with azacycloalkane amino acids. Synthesis of a potent and selective ORL1 antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.46 | 6.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL358403 | — | — | 1 | 6.65 |
| CHEMBL2371034 | — | — | 1 | 5.63 |
| CHEMBL396460 | NOCICEPTIN | — | 1 | 5.52 |
| CHEMBL266609 | — | — | 1 | 5.28 |
| CHEMBL355931 | — | — | 1 | 5.15 |
| CHEMBL140979 | — | — | 1 | 5.06 |
| CHEMBL356210 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL358403 | — | Ki | = | 222.0 | nM | 6.65 |
| CHEMBL2371034 | — | Ki | = | 2340.0 | nM | 5.63 |
| CHEMBL396460 | NOCICEPTIN | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL266609 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL355931 | — | Ki | = | 7050.0 | nM | 5.15 |
| CHEMBL140979 | — | Ki | = | 8647.0 | nM | 5.06 |
| CHEMBL356210 | — | Ki | = | 10900.0 | nM | 4.96 |