Assay Detail
Binding
CHEMBL752986
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In vitro inhibitory activity against neutral endopeptidase (NEP) was determined
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Dual metalloprotease inhibitors. III. utilization of bicyclic and monocyclic diazepinone based mercaptoacetyls
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.05 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65545 | — | — | 1 | 8.52 |
| CHEMBL299639 | — | — | 1 | 8.22 |
| CHEMBL66481 | — | — | 1 | 7.80 |
| CHEMBL66254 | — | — | 1 | 7.66 |
| CHEMBL304881 | — | — | 1 | 7.26 |
| CHEMBL305108 | — | — | 1 | 6.85 |
| CHEMBL63001 | — | — | 1 | 6.32 |
| CHEMBL417034 | — | — | 1 | 6.31 |
| CHEMBL61566 | — | — | 1 | 5.83 |
| CHEMBL62417 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65545 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL299639 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL66481 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL66254 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL304881 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL305108 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL63001 | — | IC50 | = | 484.0 | nM | 6.32 |
| CHEMBL417034 | — | IC50 | = | 486.0 | nM | 6.31 |
| CHEMBL61566 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL62417 | — | IC50 | = | 1922.0 | nM | 5.72 |