Assay Detail
Binding
CHEMBL752990
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration against neutral endopeptidase
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Dual inhibition of neutral endopeptidase and angiotensin-converting enzyme by N-phosphonomethyl and N-carboxyalkyl dipeptides
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.32 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90545 | — | — | 1 | 8.70 |
| CHEMBL89563 | — | — | 1 | 8.52 |
| CHEMBL329894 | — | — | 1 | 8.40 |
| CHEMBL10247 | THIORPHAN | -1.0 | 1 | 8.30 |
| CHEMBL328030 | — | — | 1 | 8.05 |
| CHEMBL92949 | — | — | 1 | 8.05 |
| CHEMBL329372 | — | — | 1 | 7.92 |
| CHEMBL418959 | — | — | 1 | 7.70 |
| CHEMBL93562 | — | — | 1 | 7.58 |
| CHEMBL92638 | — | — | 1 | 7.47 |
| CHEMBL93180 | — | — | 1 | 7.46 |
| CHEMBL93167 | — | — | 1 | 7.46 |
| CHEMBL313419 | — | — | 1 | 7.43 |
| CHEMBL329530 | — | — | 1 | 7.33 |
| CHEMBL328463 | — | — | 1 | 7.32 |
| CHEMBL330507 | — | — | 1 | 7.14 |
| CHEMBL91399 | — | — | 1 | 7.02 |
| CHEMBL94173 | — | — | 1 | 6.78 |
| CHEMBL92126 | — | — | 1 | 6.77 |
| CHEMBL328737 | — | — | 1 | 6.70 |
| CHEMBL420253 | — | — | 1 | 6.65 |
| CHEMBL92326 | — | — | 1 | 6.55 |
| CHEMBL329464 | — | — | 1 | 6.47 |
| CHEMBL92676 | — | — | 1 | 6.45 |
| CHEMBL92632 | — | — | 1 | 6.13 |
| CHEMBL91218 | — | — | 1 | 6.00 |
| CHEMBL93206 | — | — | 1 | - |
| CHEMBL329666 | — | — | 1 | - |
| CHEMBL327799 | — | — | 1 | - |
| CHEMBL366503 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90545 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL89563 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL329894 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL10247 | THIORPHAN | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL328030 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL92949 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL329372 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL418959 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL93562 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL92638 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL93180 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL93167 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL313419 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL329530 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL328463 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL330507 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL91399 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL94173 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL92126 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL328737 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL420253 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL92326 | — | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL329464 | — | IC50 | = | 338.0 | nM | 6.47 |
| CHEMBL92676 | — | IC50 | = | 356.0 | nM | 6.45 |
| CHEMBL92632 | — | IC50 | = | 735.0 | nM | 6.13 |
| CHEMBL91218 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL93206 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL329666 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL327799 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL366503 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL315669 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL329136 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL93785 | — | IC50 | > | 1000.0 | nM | - |