Assay Detail
Binding
CHEMBL752993
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Inhibition of neutral endopeptidase
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Ortho-substituted benzofused macrocyclic lactams as zinc metalloprotease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.62 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL150222 | — | — | 1 | 9.05 |
| CHEMBL342091 | — | — | 1 | 8.52 |
| CHEMBL357311 | — | — | 1 | 8.40 |
| CHEMBL10247 | THIORPHAN | -1.0 | 1 | 8.37 |
| CHEMBL346424 | — | — | 1 | 8.15 |
| CHEMBL146573 | — | — | 1 | 7.57 |
| CHEMBL147755 | — | — | 1 | 7.17 |
| CHEMBL148140 | — | — | 1 | 7.00 |
| CHEMBL149367 | — | — | 1 | 6.87 |
| CHEMBL149841 | — | — | 1 | 6.65 |
| CHEMBL433702 | — | — | 1 | 6.05 |
| CHEMBL423574 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL150222 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL342091 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL357311 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL10247 | THIORPHAN | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL346424 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL146573 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL147755 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL148140 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL149367 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL149841 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL433702 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL423574 | — | IC50 | > | 10000.0 | nM | - |