Assay Detail
Binding
CHEMBL753045
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Binding affinity against Na+ channels
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
From hit to lead. Analyzing structure-profile relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.14 | 6.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116463 | — | — | 1 | 6.78 |
| CHEMBL113956 | — | — | 1 | 6.36 |
| CHEMBL117537 | — | — | 1 | 6.27 |
| CHEMBL116735 | — | — | 1 | 6.13 |
| CHEMBL326263 | — | — | 1 | 5.87 |
| CHEMBL420499 | — | — | 1 | 5.83 |
| CHEMBL325516 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116463 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL113956 | — | IC50 | = | 438.0 | nM | 6.36 |
| CHEMBL117537 | — | IC50 | = | 539.0 | nM | 6.27 |
| CHEMBL116735 | — | IC50 | = | 737.0 | nM | 6.13 |
| CHEMBL326263 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL420499 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL325516 | — | IC50 | = | 1800.0 | nM | 5.75 |