Assay Detail
Binding
CHEMBL753099
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Potency to displace [3H]IMI binding to Nicotinic acetylcholine receptor from Drosophila head membranes
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Drosophila melanogaster |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structural features of azidopyridinyl neonicotinoid probes conferring high affinity and selectivity for mammalian alpha4beta2 and Drosophila nicotinic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 7.12 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL100491 | — | — | 1 | 9.92 |
| CHEMBL97798 | — | — | 1 | 9.46 |
| CHEMBL319510 | — | — | 1 | 9.14 |
| CHEMBL95367 | DEHYDROIMIDACLOPRID | — | 1 | 9.07 |
| CHEMBL95352 | THIACLOPRID OLEFIN | — | 1 | 8.85 |
| CHEMBL406819 | IMIDACLOPRID | — | 1 | 8.66 |
| CHEMBL98451 | — | — | 1 | 8.41 |
| CHEMBL95531 | — | — | 1 | 7.89 |
| CHEMBL97343 | 5-AZIDOIMIDACLOPRID | — | 1 | 7.62 |
| CHEMBL95904 | — | — | 1 | 7.55 |
| CHEMBL72675 | — | — | 1 | 7.00 |
| CHEMBL6623 | EPIBATIDINE | — | 1 | 6.66 |
| CHEMBL318765 | — | — | 1 | 6.34 |
| CHEMBL97016 | — | — | 1 | 6.27 |
| CHEMBL319885 | — | — | 1 | 6.12 |
| CHEMBL309804 | DESNITROIMIDACLOPRID | — | 1 | 6.10 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 5.70 |
| CHEMBL330079 | — | — | 1 | 5.50 |
| CHEMBL327625 | — | — | 1 | 5.44 |
| CHEMBL316493 | — | — | 1 | 5.24 |
| CHEMBL317288 | — | — | 1 | 5.14 |
| CHEMBL96405 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL100491 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL97798 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL319510 | — | Ki | = | 0.72 | nM | 9.14 |
| CHEMBL95367 | DEHYDROIMIDACLOPRID | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL95352 | THIACLOPRID OLEFIN | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL406819 | IMIDACLOPRID | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL98451 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL95531 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL97343 | 5-AZIDOIMIDACLOPRID | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL95904 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL72675 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL6623 | EPIBATIDINE | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL318765 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL97016 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL319885 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL309804 | DESNITROIMIDACLOPRID | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL3 | NICOTINE | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL330079 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL327625 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL316493 | — | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL317288 | — | Ki | = | 7200.0 | nM | 5.14 |
| CHEMBL96405 | — | Ki | = | 30000.0 | nM | 4.52 |