Assay Detail
Binding
CHEMBL753145
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards opioid receptor kappa was determined
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Highly selective kappa-opioid analgesics. 2. Synthesis and structure-activity relationships of novel N-[(2-aminocyclohexyl)aryl]acetamide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 6.74 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL544960 | — | — | 1 | 8.43 |
| CHEMBL541804 | — | — | 1 | 8.15 |
| CHEMBL555100 | — | — | 1 | 7.77 |
| CHEMBL556414 | — | — | 1 | 7.75 |
| CHEMBL536550 | — | — | 1 | 7.03 |
| CHEMBL558227 | — | — | 1 | 6.84 |
| CHEMBL553010 | — | — | 1 | 6.81 |
| CHEMBL553665 | — | — | 1 | 6.75 |
| CHEMBL540277 | — | — | 1 | 6.75 |
| CHEMBL545654 | — | — | 1 | 6.58 |
| CHEMBL43104 | — | — | 1 | 6.09 |
| CHEMBL542102 | — | — | 1 | 5.70 |
| CHEMBL555649 | — | — | 1 | 5.09 |
| CHEMBL554205 | — | — | 1 | 4.60 |
| CHEMBL2094047 | — | — | 1 | - |
| CHEMBL2093981 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL544960 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL541804 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL555100 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL556414 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL536550 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL558227 | — | Ki | = | 146.0 | nM | 6.84 |
| CHEMBL553010 | — | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL553665 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL540277 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL545654 | — | Ki | = | 261.0 | nM | 6.58 |
| CHEMBL43104 | — | Ki | = | 816.0 | nM | 6.09 |
| CHEMBL542102 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL555649 | — | Ki | = | 8100.0 | nM | 5.09 |
| CHEMBL554205 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL2094047 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2093981 | — | Ki | > | 1000.0 | nM | - |