Assay Detail
Binding
CHEMBL753263
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Opioid receptor delta 1 binding to bovine striatal membrane
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-Methyl and N-cyclopropylmethyl-14,14-[dithiobis[(2-oxo-2,1-ethanediyl)imino]]bis(7,8-dihydro-5-methyl-morphinone) MET-TAMO and N-CPM-MET-TAMO: Synthesis and opioid binding properties
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.79 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2304424 | — | — | 1 | 8.28 |
| CHEMBL41098 | — | — | 1 | 7.96 |
| CHEMBL290701 | — | — | 1 | 7.62 |
| CHEMBL297605 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2304424 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL41098 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL290701 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL297605 | — | IC50 | = | 52.0 | nM | 7.28 |