Assay Detail
Functional
CHEMBL753284
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Agonist activity by measuring inositol phosphate accumulation in 1321N1 human astrocytoma cells stably expressing human P2Y purinoceptor 2
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Adenine nucleotide analogues locked in a Northern methanocarba conformation: enhanced stability and potency as P2Y(1) receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.21 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14249 | ADENOSINE TRIPHOSPHATE | 2.0 | 1 | 7.07 |
| CHEMBL302077 | — | — | 1 | 7.04 |
| CHEMBL2373324 | — | — | 1 | 6.71 |
| CHEMBL2373323 | — | — | 1 | 5.72 |
| CHEMBL1368696 | — | — | 1 | 5.64 |
| CHEMBL2373377 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14249 | ADENOSINE TRIPHOSPHATE | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL302077 | — | EC50 | = | 91.0 | nM | 7.04 |
| CHEMBL2373324 | — | EC50 | = | 197.0 | nM | 6.71 |
| CHEMBL2373323 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1368696 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL2373377 | — | EC50 | = | 8400.0 | nM | 5.08 |