Assay Detail
Functional
CHEMBL753285
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Measure of Agonist Potency at human P2Y purinoceptor 2 (hP2Y2) stably expressed in 131N1 astrocytoma cell
6
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.09 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL606210 | N-METHANOCARBA-UTP | — | 2 | 8.10 |
| CHEMBL2111533 | — | — | 2 | 7.07 |
| CHEMBL752 | ADENOSINE PHOSPHATE | 4.0 | 2 | 7.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL606210 | N-METHANOCARBA-UTP | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL606210 | N-METHANOCARBA-UTP | EC50 | = | 15.9 | nM | 7.80 |
| CHEMBL2111533 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL752 | ADENOSINE PHOSPHATE | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL2111533 | — | EC50 | = | 91.0 | nM | 7.04 |
| CHEMBL752 | ADENOSINE PHOSPHATE | EC50 | = | 3700.0 | nM | 5.43 |