Assay Detail
Binding
CHEMBL753309
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Tested for binding activity against Opioid receptor delta 2 using [3H]DSLET ligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of naltrexone-derived delta-opioid antagonists. Role of conformation of the delta address moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.57 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL610046 | — | — | 1 | 9.92 |
| CHEMBL610550 | — | — | 1 | 8.82 |
| CHEMBL101519 | — | — | 1 | 8.74 |
| CHEMBL610292 | — | — | 1 | 8.11 |
| CHEMBL252172 | BNTX | — | 1 | 8.00 |
| CHEMBL610290 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL610046 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL610550 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL101519 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL610292 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL252172 | BNTX | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL610290 | — | Ki | = | 15.0 | nM | 7.82 |