Assay Detail

CHEMBL753419

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Binding

Opioid receptor activity was evaluated using guinea pig ileum (GPI) assay

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Cavia porcellus
Tissue	Ileum
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability.

Bilsky EJ, Egleton RD, Mitchell SA, Palian MM, Davis P, Huber JD, Jones H, Yamamura HI, Janders J, Davis TP, Porreca F, Hruby VJ, Polt R.
J Med Chem (2000) 43 : 2586 -2590
PubMed 10891118 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.43	7.60

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1790710	—	—	1	7.60
CHEMBL70	MORPHINE	4.0	1	7.26

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1790710	—	IC50	=	25.0	nM	7.60
CHEMBL70	MORPHINE	IC50	=	54.7	nM	7.26