Assay Detail
Functional
CHEMBL753455
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Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
New synthesis of benzo-delta-carbolines, cryptolepines, and their salts: in vitro cytotoxic, antiplasmodial, and antitrypanosomal activities of delta-carbolines, benzo-delta-carbolines, and cryptolepines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.18 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL176533 | — | — | 1 | 7.21 |
| CHEMBL172138 | — | — | 1 | 7.00 |
| CHEMBL172017 | — | — | 1 | 6.48 |
| CHEMBL369051 | — | — | 1 | 6.32 |
| CHEMBL368186 | — | — | 1 | 5.96 |
| CHEMBL369675 | — | — | 1 | 5.96 |
| CHEMBL424964 | — | — | 1 | 5.96 |
| CHEMBL172918 | — | — | 1 | 5.89 |
| CHEMBL369473 | — | — | 1 | 5.82 |
| CHEMBL367658 | — | — | 1 | 5.80 |
| CHEMBL172137 | — | — | 1 | 5.66 |
| CHEMBL367738 | — | — | 1 | 5.66 |
| CHEMBL369038 | — | — | 1 | 5.19 |
| CHEMBL424954 | — | — | 1 | 4.85 |
| CHEMBL366482 | — | — | 1 | 4.83 |
| CHEMBL174540 | — | — | 1 | 4.79 |
| CHEMBL171841 | — | — | 1 | 4.78 |
| CHEMBL368165 | — | — | 1 | 4.66 |
| CHEMBL366607 | — | — | 1 | 4.63 |
| CHEMBL368642 | — | — | 1 | 4.62 |
| CHEMBL368103 | — | — | 1 | 4.53 |
| CHEMBL172479 | — | — | 1 | 4.51 |
| CHEMBL367105 | — | — | 1 | 4.48 |
| CHEMBL224248 | QUINDOLINE | — | 1 | 4.44 |
| CHEMBL174748 | — | — | 1 | 4.42 |
| CHEMBL176545 | — | — | 1 | 4.34 |
| CHEMBL176519 | — | — | 1 | 4.25 |
| CHEMBL368594 | — | — | 1 | 4.17 |
| CHEMBL173684 | — | — | 1 | 4.13 |
| CHEMBL176893 | — | — | 1 | 4.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL176533 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL172138 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL172017 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL369051 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL368186 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL369675 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL424964 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL172918 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL369473 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL367658 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL172137 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL367738 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL369038 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL424954 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL366482 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL174540 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL171841 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL368165 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL366607 | — | IC50 | = | 23600.0 | nM | 4.63 |
| CHEMBL368642 | — | IC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL368103 | — | IC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL172479 | — | IC50 | = | 30900.0 | nM | 4.51 |
| CHEMBL367105 | — | IC50 | = | 33100.0 | nM | 4.48 |
| CHEMBL224248 | QUINDOLINE | IC50 | = | 36200.0 | nM | 4.44 |
| CHEMBL174748 | — | IC50 | = | 38500.0 | nM | 4.42 |
| CHEMBL176545 | — | IC50 | = | 45600.0 | nM | 4.34 |
| CHEMBL176519 | — | IC50 | = | 56500.0 | nM | 4.25 |
| CHEMBL368594 | — | IC50 | = | 66800.0 | nM | 4.17 |
| CHEMBL173684 | — | IC50 | = | 74600.0 | nM | 4.13 |
| CHEMBL176893 | — | IC50 | = | 74600.0 | nM | 4.13 |
| CHEMBL368478 | — | IC50 | = | 129000.0 | nM | - |
| CHEMBL175276 | — | IC50 | = | 104000.0 | nM | - |
| CHEMBL175417 | — | IC50 | = | 259000.0 | nM | - |