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Assay Detail

CHEMBL753457

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Functional
In vitro activity against Plasmodium falciparum
ChEMBL ↗
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Expert

Target

Plasmodium falciparum (CHEMBL364) ↗
Type ORGANISM
Organism Plasmodium falciparum

Publication

Antimalarial activity of compounds interfering with Plasmodium falciparum phospholipid metabolism: comparison between mono- and bisquaternary ammonium salts.
Calas M, Ancelin ML, Cordina G, Portefaix P, Piquet G, Vidal-Sailhan V, Vial H.
J Med Chem (2000) 43 : 505 -516
PubMed 10669577 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 53 6.70 9.19

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL358520 — — 1 9.19
CHEMBL423396 — — 1 8.96
CHEMBL357523 — — 1 8.80
CHEMBL151895 — — 1 8.40
CHEMBL358063 — — 1 8.31
CHEMBL343452 — — 1 8.28
CHEMBL422319 — — 1 8.12
CHEMBL149661 — — 1 7.89
CHEMBL116717 — — 1 7.48
CHEMBL175697 — — 1 7.36
CHEMBL146507 — — 1 7.35
CHEMBL116718 — — 1 7.19
CHEMBL119701 — — 1 7.05
CHEMBL324402 — — 1 6.96
CHEMBL110737 — — 1 6.85
CHEMBL146860 — — 1 6.85
CHEMBL421897 — — 1 6.82
CHEMBL119073 — — 1 6.82
CHEMBL148551 — — 1 6.75
CHEMBL116428 — — 1 6.68
CHEMBL146287 — — 1 6.66
CHEMBL149894 — — 1 6.66
CHEMBL146916 — — 1 6.64
CHEMBL120016 — — 1 6.58
CHEMBL148470 — — 1 6.57
CHEMBL148964 — — 1 6.57
CHEMBL149870 — — 1 6.57
CHEMBL119557 — — 1 6.47
CHEMBL147514 — — 1 6.44
CHEMBL147166 — — 1 6.42

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL358520 — IC50 = 0.64 nM 9.19
CHEMBL423396 — IC50 = 1.1 nM 8.96
CHEMBL357523 — IC50 = 1.6 nM 8.80
CHEMBL151895 — IC50 = 4.0 nM 8.40
CHEMBL358063 — IC50 = 4.9 nM 8.31
CHEMBL343452 — IC50 = 5.3 nM 8.28
CHEMBL422319 — IC50 = 7.6 nM 8.12
CHEMBL149661 — IC50 = 13.0 nM 7.89
CHEMBL116717 — IC50 = 33.0 nM 7.48
CHEMBL175697 — IC50 = 44.0 nM 7.36
CHEMBL146507 — IC50 = 45.0 nM 7.35
CHEMBL116718 — IC50 = 64.0 nM 7.19
CHEMBL119701 — IC50 = 90.0 nM 7.05
CHEMBL324402 — IC50 = 110.0 nM 6.96
CHEMBL146860 — IC50 = 140.0 nM 6.85
CHEMBL110737 — IC50 = 140.0 nM 6.85
CHEMBL421897 — IC50 = 150.0 nM 6.82
CHEMBL119073 — IC50 = 150.0 nM 6.82
CHEMBL148551 — IC50 = 180.0 nM 6.75
CHEMBL116428 — IC50 = 210.0 nM 6.68
CHEMBL146287 — IC50 = 220.0 nM 6.66
CHEMBL149894 — IC50 = 220.0 nM 6.66
CHEMBL146916 — IC50 = 230.0 nM 6.64
CHEMBL120016 — IC50 = 260.0 nM 6.58
CHEMBL149870 — IC50 = 270.0 nM 6.57
CHEMBL148964 — IC50 = 270.0 nM 6.57
CHEMBL148470 — IC50 = 270.0 nM 6.57
CHEMBL119557 — IC50 = 340.0 nM 6.47
CHEMBL147514 — IC50 = 360.0 nM 6.44
CHEMBL147166 — IC50 = 380.0 nM 6.42
CHEMBL148575 — IC50 = 420.0 nM 6.38
CHEMBL423209 — IC50 = 430.0 nM 6.37
CHEMBL119520 — IC50 = 480.0 nM 6.32
CHEMBL109873 — IC50 = 500.0 nM 6.30
CHEMBL357621 — IC50 = 540.0 nM 6.27
CHEMBL149561 — IC50 = 620.0 nM 6.21
CHEMBL149285 — IC50 = 670.0 nM 6.17
CHEMBL332670 — IC50 = 700.0 nM 6.16
CHEMBL5314343 — IC50 = 800.0 nM 6.10
CHEMBL347545 — IC50 = 810.0 nM 6.09
CHEMBL117619 — IC50 = 840.0 nM 6.08
CHEMBL331107 — IC50 = 1500.0 nM 5.82
CHEMBL1202245 — IC50 = 1800.0 nM 5.75
CHEMBL149489 — IC50 = 3000.0 nM 5.52
CHEMBL146237 — IC50 = 3850.0 nM 5.42
CHEMBL149390 — IC50 = 5000.0 nM 5.30
CHEMBL148729 — IC50 = 9700.0 nM 5.01
CHEMBL342090 — IC50 = 10800.0 nM 4.97
CHEMBL149118 — IC50 = 26000.0 nM 4.58
CHEMBL149119 — IC50 = 800000.0 nM -