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Assay Detail

CHEMBL753460

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Functional
In vitro activity against Plasmodium falciparum D6
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Intermediate

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Bisquinolines. 1. N,N-bis(7-chloroquinolin-4-yl)alkanediamines with potential against chloroquine-resistant malaria.
Vennerstrom JL, Ellis WY, Ager AL, Andersen SL, Gerena L, Milhous WK.
J Med Chem (1992) 35 : 2129 -2134
PubMed 1597862 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 8.09 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL441251 1 9.00
CHEMBL67277 1 8.72
CHEMBL308892 1 8.60
CHEMBL63724 1 8.57
CHEMBL420179 1 8.52
CHEMBL304970 1 8.46
CHEMBL67336 1 8.25
CHEMBL303604 1 8.24
CHEMBL303933 PIPERAQUINE 3.0 1 8.08
CHEMBL76 CHLOROQUINE 4.0 1 8.05
CHEMBL66885 1 7.82
CHEMBL66998 1 7.77
CHEMBL63342 1 7.68
CHEMBL66616 1 7.22
CHEMBL66165 1 6.41

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL441251 IC50 = 1.0 nM 9.00
CHEMBL67277 IC50 = 1.9 nM 8.72
CHEMBL308892 IC50 = 2.5 nM 8.60
CHEMBL63724 IC50 = 2.7 nM 8.57
CHEMBL420179 IC50 = 3.0 nM 8.52
CHEMBL304970 IC50 = 3.5 nM 8.46
CHEMBL67336 IC50 = 5.6 nM 8.25
CHEMBL303604 IC50 = 5.7 nM 8.24
CHEMBL303933 PIPERAQUINE IC50 = 8.3 nM 8.08
CHEMBL76 CHLOROQUINE IC50 = 8.9 nM 8.05
CHEMBL66885 IC50 = 15.0 nM 7.82
CHEMBL66998 IC50 = 17.0 nM 7.77
CHEMBL63342 IC50 = 21.0 nM 7.68
CHEMBL66616 IC50 = 60.0 nM 7.22
CHEMBL66165 IC50 = 390.0 nM 6.41