Assay Detail
Binding
CHEMBL753466
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Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 using [3H]nicotine as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Target
Neuronal acetylcholine receptor; alpha4/beta2 (CHEMBL1907596) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Synthesis and nicotinic binding of novel phenyl derivatives of UB-165. Identifying factors associated with alpha7 selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.31 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1086655 | — | — | 1 | 9.57 |
| CHEMBL444572 | — | — | 1 | 9.37 |
| CHEMBL96828 | — | — | 1 | 8.32 |
| CHEMBL329084 | — | — | 1 | 7.67 |
| CHEMBL93983 | — | — | 1 | 6.63 |
| CHEMBL419700 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1086655 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL444572 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL96828 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL329084 | — | Ki | = | 21.4 | nM | 7.67 |
| CHEMBL93983 | — | Ki | = | 234.0 | nM | 6.63 |
| CHEMBL419700 | — | Ki | > | 50000.0 | nM | - |