Assay Detail
Functional
CHEMBL753472
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha4-beta2 expressed in Xenopus oocytes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Oocyte |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha4/beta2 (CHEMBL1907596) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Epibatidine structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.02 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | — | 1 | 7.85 |
| CHEMBL301901 | — | — | 1 | 7.03 |
| CHEMBL56682 | — | — | 1 | 6.59 |
| CHEMBL56817 | DESCHLOROEPIBATIDINE | — | 1 | 5.44 |
| CHEMBL56358 | — | — | 1 | 5.12 |
| CHEMBL667 | ACETYLCHOLINE | 4.0 | 1 | 4.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL301901 | — | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL56682 | — | EC50 | = | 254.0 | nM | 6.59 |
| CHEMBL56817 | DESCHLOROEPIBATIDINE | EC50 | = | 3630.0 | nM | 5.44 |
| CHEMBL56358 | — | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL667 | ACETYLCHOLINE | EC50 | = | 87000.0 | nM | 4.06 |