Assay Detail
Binding
CHEMBL753533
Review assay metadata, readout intent, target linkage, and publication context from the same page.
[3H]-Cl-DPDPE competition binding assay using human cloned opioid receptor delta 1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of the first N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphan to possess highly potent and selective opioid delta receptor antagonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.97 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL567175 | NALTRINDOLE | — | 1 | 10.15 |
| CHEMBL329470 | — | — | 1 | 9.02 |
| CHEMBL94741 | — | — | 1 | 8.68 |
| CHEMBL329754 | — | — | 1 | 8.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL567175 | NALTRINDOLE | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL329470 | — | Ki | = | 0.96 | nM | 9.02 |
| CHEMBL94741 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL329754 | — | Ki | = | 9.3 | nM | 8.03 |