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Assay Detail

CHEMBL753544

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]-naloxone from Opioid receptor delta 1
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Delta-type opioid receptor (CHEMBL236)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

8-acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as orphanin FQ receptor agonists.
Wichmann J, Adam G, Röver S, Cesura AM, Dautzenberg FM, Jenck F.
Bioorg Med Chem Lett (1999) 9 : 2343 -2348
PubMed 10476866 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 10 6.80 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL355202 1 7.00
CHEMBL312021 1 6.80
CHEMBL78156 1 6.80
CHEMBL281274 1 6.60
CHEMBL1907858 1 -
CHEMBL77324 1 -
CHEMBL75676 1 -
CHEMBL419272 1 -
CHEMBL308522 1 -
CHEMBL306150 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL355202 Ki = 100.0 nM 7.00
CHEMBL312021 Ki = 158.49 nM 6.80
CHEMBL78156 Ki = 158.49 nM 6.80
CHEMBL281274 Ki = 251.19 nM 6.60
CHEMBL1907858 Ki < 501.19 nM -
CHEMBL77324 Ki < 501.19 nM -
CHEMBL75676 Ki < 501.19 nM -
CHEMBL419272 Ki < 501.19 nM -
CHEMBL308522 Ki < 501.19 nM -
CHEMBL306150 Ki < 501.19 nM -