Assay Detail
Binding
CHEMBL753666
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Binding affinity against opioid receptor delta 1 using [3H]naltrindole as radioligand in guinea pig brain membranes.
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
10-Ketomorphinan and 3-substituted-3-desoxymorphinan analogues as mixed kappa and micro opioid ligands: synthesis and biological evaluation of their binding affinity at opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 7.03 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300033 | — | — | 1 | 9.00 |
| CHEMBL301804 | — | — | 1 | 9.00 |
| CHEMBL49269 | CYCLORPHAN | — | 1 | 8.72 |
| CHEMBL279968 | ETHYLKETOCYCLAZOCINE | — | 1 | 8.47 |
| CHEMBL433272 | — | — | 1 | 8.40 |
| CHEMBL592 | LEVORPHANOL | 4.0 | 1 | 8.38 |
| CHEMBL301160 | BUTORPHAN | — | 1 | 8.23 |
| CHEMBL48390 | — | — | 1 | 8.01 |
| CHEMBL297292 | — | — | 1 | 7.89 |
| CHEMBL297467 | — | — | 1 | 7.80 |
| CHEMBL296282 | — | — | 1 | 7.30 |
| CHEMBL299220 | — | — | 1 | 6.82 |
| CHEMBL298027 | — | — | 1 | 6.82 |
| CHEMBL49143 | — | — | 1 | 6.75 |
| CHEMBL48241 | — | — | 1 | 6.58 |
| CHEMBL49106 | — | — | 1 | 6.42 |
| CHEMBL298688 | — | — | 1 | 6.39 |
| CHEMBL300877 | — | — | 1 | 6.22 |
| CHEMBL295237 | — | — | 1 | 6.16 |
| CHEMBL299189 | — | — | 1 | 6.10 |
| CHEMBL295402 | — | — | 1 | 5.96 |
| CHEMBL432120 | — | — | 1 | 5.92 |
| CHEMBL48420 | — | — | 1 | 5.82 |
| CHEMBL48974 | — | — | 1 | 5.75 |
| CHEMBL48157 | — | — | 1 | 5.72 |
| CHEMBL298571 | — | — | 1 | 5.64 |
| CHEMBL49318 | — | — | 1 | 5.60 |
| CHEMBL299132 | — | — | 1 | - |
| CHEMBL47488 | — | — | 1 | - |
| CHEMBL296328 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300033 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL301804 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL49269 | CYCLORPHAN | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL279968 | ETHYLKETOCYCLAZOCINE | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL433272 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL592 | LEVORPHANOL | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL301160 | BUTORPHAN | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL48390 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL297292 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL297467 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL296282 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL299220 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL298027 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL49143 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL48241 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL49106 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL298688 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL300877 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL295237 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL299189 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL295402 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL432120 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL48420 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL48974 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL48157 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL298571 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL49318 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL296304 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL300023 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL42055 | E-FLUPENTIXOL | Ki | > | 10000.0 | nM | - |
| CHEMBL46320 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL298446 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL48816 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL48936 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL296328 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL47488 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL299132 | — | Ki | > | 10000.0 | nM | - |