Assay Detail
Binding
CHEMBL753670
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Binding affinity of compound was determined against Opioid receptor delta 1 from a native receptor in guinea pig
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation, and receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as kappa-opioid receptor agonists endowed with antinociceptive and antiamnesic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.74 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL567175 | NALTRINDOLE | — | 1 | 9.80 |
| CHEMBL127828 | — | — | 1 | 7.82 |
| CHEMBL127969 | — | — | 1 | 6.98 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 6.34 |
| CHEMBL124015 | — | — | 1 | - |
| CHEMBL440765 | U-69593 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL567175 | NALTRINDOLE | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL127828 | — | Ki | = | 15.3 | nM | 7.82 |
| CHEMBL127969 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL70 | MORPHINE | Ki | = | 456.0 | nM | 6.34 |
| CHEMBL124015 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL440765 | U-69593 | Ki | > | 10000.0 | nM | - |