Assay Detail
Binding
CHEMBL753703
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In vitro binding affinity against human norepinephrine transporter in human embryonic kidney cell line by using [125I]-RTI-55 radioligand
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | kidney |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, radiosynthesis, and biological evaluation of carbon-11 and iodine-123 labeled 2beta-carbomethoxy-3beta-[4'-((Z)-2-haloethenyl)phenyl]tropanes: candidate radioligands for in vivo imaging of the serotonin transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.39 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14531 | — | — | 1 | 8.60 |
| CHEMBL14257 | — | — | 1 | 8.25 |
| CHEMBL14305 | — | — | 1 | 6.96 |
| CHEMBL14924 | — | — | 1 | 6.79 |
| CHEMBL275212 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14531 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL14257 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL14305 | — | Ki | = | 111.0 | nM | 6.96 |
| CHEMBL14924 | — | Ki | = | 161.0 | nM | 6.79 |
| CHEMBL275212 | — | Ki | = | 450.0 | nM | 6.35 |