Assay Detail
Functional
CHEMBL753711
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration required to stimulate binding of GTPgammaS to ORL1 receptor was determined using scintillation proximity assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
High-affinity, non-peptide agonists for the ORL1 (orphanin FQ/nociceptin) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.46 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281274 | — | — | 1 | 7.40 |
| CHEMBL27460 | — | — | 1 | 7.06 |
| CHEMBL280827 | — | — | 1 | 6.29 |
| CHEMBL284414 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281274 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL27460 | — | EC50 | = | 87.0 | nM | 7.06 |
| CHEMBL280827 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL284414 | — | EC50 | = | 7900.0 | nM | 5.10 |