Assay Detail
Binding
CHEMBL753763
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Binding affinity to Opioid receptor delta 1 by competitive inhibition of radioligand [3H]DPDPE using cloned receptors transiently expressed on CHO cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and opioid activity of conformationally constrained dynorphin A analogues. 2. Conformational constraint in the "address" sequence.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.63 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408024 | — | — | 1 | 8.09 |
| CHEMBL408360 | — | — | 1 | 7.66 |
| CHEMBL405618 | ANALOG OF DYNORPHIN A | — | 1 | 7.55 |
| CHEMBL412413 | — | — | 1 | 7.55 |
| CHEMBL264481 | — | — | 1 | 7.32 |
| CHEMBL263366 | — | — | 1 | 6.75 |
| CHEMBL2370861 | — | — | 1 | 6.37 |
| CHEMBL406899 | — | — | 1 | 5.89 |
| CHEMBL407076 | — | — | 1 | 5.80 |
| CHEMBL414921 | — | — | 1 | 5.72 |
| CHEMBL412364 | — | — | 1 | 5.48 |
| CHEMBL386618 | — | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408024 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL408360 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL405618 | ANALOG OF DYNORPHIN A | Ki | = | 28.4 | nM | 7.55 |
| CHEMBL412413 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL264481 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL263366 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL2370861 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL406899 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL407076 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL414921 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL412364 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL386618 | — | Ki | = | 4100.0 | nM | 5.39 |