Assay Detail
Binding
CHEMBL753767
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In vitro binding affinity against Opioid receptor mu 1 from bovine caudate nucleus determined in presence of [3H]DAGO (1 nM)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Conjugate addition ligands of opioid antagonists. Methacrylate esters and ethers of 6 alpha- and 6 beta-naltrexol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.89 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166355 | — | — | 1 | 9.74 |
| CHEMBL163704 | — | — | 1 | 9.00 |
| CHEMBL76023 | — | — | 1 | 8.82 |
| CHEMBL610531 | — | — | 1 | 8.74 |
| CHEMBL3084322 | — | — | 1 | 8.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166355 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL163704 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL76023 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL610531 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3084322 | — | IC50 | = | 6.8 | nM | 8.17 |