Assay Detail
Binding
CHEMBL753771
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Activity was evaluated by inhibition of the binding of 0.8 nM [3H]- DAMGO at Opioid receptor mu 1 binding site
19
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Asymmetric syntheses, opioid receptor affinities, and antinociceptive effects of 8-amino-5,9-methanobenzocyclooctenes, a new class of structural analogues of the morphine alkaloids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.22 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70 | MORPHINE | 4.0 | 1 | 9.05 |
| CHEMBL294226 | — | — | 3 | 8.70 |
| CHEMBL431947 | — | — | 2 | 7.71 |
| CHEMBL60270 | — | — | 1 | 7.56 |
| CHEMBL409026 | — | — | 2 | 7.39 |
| CHEMBL57879 | — | — | 2 | 7.38 |
| CHEMBL58059 | — | — | 1 | 7.04 |
| CHEMBL61644 | — | — | 1 | 6.99 |
| CHEMBL418460 | — | — | 1 | 6.75 |
| CHEMBL301421 | — | — | 2 | 6.53 |
| CHEMBL299460 | — | — | 2 | 6.08 |
| CHEMBL59840 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70 | MORPHINE | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL294226 | — | Ki | = | 1.99 | nM | 8.70 |
| CHEMBL294226 | — | Ki | = | 1.99 | nM | 8.70 |
| CHEMBL294226 | — | Ki | = | 2.29 | nM | 8.64 |
| CHEMBL431947 | — | Ki | = | 19.3 | nM | 7.71 |
| CHEMBL431947 | — | Ki | = | 25.2 | nM | 7.60 |
| CHEMBL60270 | — | Ki | = | 27.7 | nM | 7.56 |
| CHEMBL409026 | — | Ki | = | 40.6 | nM | 7.39 |
| CHEMBL57879 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL409026 | — | Ki | = | 41.2 | nM | 7.38 |
| CHEMBL58059 | — | Ki | = | 91.6 | nM | 7.04 |
| CHEMBL61644 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL418460 | — | Ki | = | 179.0 | nM | 6.75 |
| CHEMBL301421 | — | Ki | = | 297.0 | nM | 6.53 |
| CHEMBL57879 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL299460 | — | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL299460 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL301421 | — | Ki | = | 2020.0 | nM | 5.70 |
| CHEMBL59840 | — | Ki | = | 3800.0 | nM | 5.42 |