Assay Detail
Binding
CHEMBL753773
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Binding affinity towards opioid receptor mu 1
9
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Phenylmorphans and analogues: opioid receptor subtype selectivity and effect of conformation on activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.76 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70 | MORPHINE | 4.0 | 1 | 9.30 |
| CHEMBL285250 | — | — | 2 | 8.47 |
| CHEMBL290855 | — | — | 1 | 8.06 |
| CHEMBL287726 | — | — | 3 | 7.75 |
| CHEMBL36707 | — | — | 1 | 7.12 |
| CHEMBL31421 | — | — | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70 | MORPHINE | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL285250 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL290855 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL285250 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL287726 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL287726 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL36707 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL31421 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL287726 | — | Ki | = | 140.0 | nM | 6.85 |