Assay Detail
Binding
CHEMBL753816
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Inhibitory concentration was determined against delta-opioid receptor using [3H]- DPDPE radioligand
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Isothiocyanate-substituted benzyl ether opioid receptor ligands derived from 6 beta-naltrexol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.79 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31421 | — | — | 1 | 8.74 |
| CHEMBL345208 | — | — | 1 | 8.74 |
| CHEMBL2112732 | — | — | 1 | 8.54 |
| CHEMBL154510 | — | — | 1 | 8.19 |
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 8.00 |
| CHEMBL152351 | — | — | 1 | 7.92 |
| CHEMBL347674 | — | — | 1 | 7.68 |
| CHEMBL152327 | — | — | 1 | 7.66 |
| CHEMBL468469 | — | — | 1 | 7.50 |
| CHEMBL352224 | — | — | 1 | 7.46 |
| CHEMBL440765 | U-69593 | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31421 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL345208 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL2112732 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL154510 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL19019 | NALTREXONE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL152351 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL347674 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL152327 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL468469 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL352224 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL440765 | U-69593 | IC50 | = | 4970.0 | nM | 5.30 |