Assay Detail
Binding
CHEMBL753818
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Tested for the binding affinity against the Delta opioid receptor in guinea pig brain using [3H]DPDPE
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and opioid receptor affinity of a series of aralkyl ethers of 6 alpha- and 6 beta-naltrexol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.70 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2111914 | — | — | 1 | 8.85 |
| CHEMBL2112732 | — | — | 1 | 8.54 |
| CHEMBL2112740 | — | — | 1 | 8.26 |
| CHEMBL2111912 | — | — | 1 | 8.18 |
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 8.00 |
| CHEMBL2112730 | — | — | 1 | 7.96 |
| CHEMBL2111913 | — | — | 1 | 7.72 |
| CHEMBL2111911 | — | — | 1 | 7.70 |
| CHEMBL2112729 | — | — | 1 | 7.60 |
| CHEMBL140278 | — | — | 2 | 7.58 |
| CHEMBL423341 | — | — | 1 | 7.52 |
| CHEMBL2111916 | — | — | 1 | 7.44 |
| CHEMBL2112736 | — | — | 1 | 7.32 |
| CHEMBL31421 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2111914 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2112732 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL2112740 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL2111912 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL19019 | NALTREXONE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2112730 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2111913 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2111911 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2112729 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL140278 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL423341 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL140278 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2111916 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL2112736 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL31421 | — | IC50 | = | 5000.0 | nM | 5.30 |