Assay Detail
Binding
CHEMBL753852
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Displacement of [3H]EK from Opioid receptor delta 1 in guinea pig brain membrane
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Opioid agonist and antagonist bivalent ligands. The relationship between spacer length and selectivity at multiple opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.32 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3350130 | — | — | 1 | 8.31 |
| CHEMBL3350137 | — | — | 1 | 8.19 |
| CHEMBL3350138 | — | — | 1 | 8.11 |
| CHEMBL3350129 | — | — | 1 | 7.92 |
| CHEMBL3350128 | — | — | 1 | 7.58 |
| CHEMBL610018 | — | — | 1 | 7.42 |
| CHEMBL3350140 | — | — | 1 | 7.38 |
| CHEMBL3350132 | — | — | 1 | 7.30 |
| CHEMBL3350135 | — | — | 1 | 7.07 |
| CHEMBL3350127 | — | — | 1 | 7.00 |
| CHEMBL3350133 | — | — | 1 | 6.96 |
| CHEMBL3350134 | — | — | 1 | 6.70 |
| CHEMBL607319 | — | — | 1 | 6.32 |
| CHEMBL3350139 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3350130 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL3350137 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL3350138 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL3350129 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL3350128 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL610018 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL3350140 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL3350132 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL3350135 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL3350127 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL3350133 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL3350134 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL607319 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL3350139 | — | Ki | = | 700.0 | nM | 6.16 |