Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL754071

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro growth inhibition of Plasmodium falciparum FcB1R
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Expert

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Antiplasmodial activity and cytotoxicity of bis-, tris-, and tetraquinolines with linear or cyclic amino linkers.
Girault S, Grellier P, Berecibar A, Maes L, Lemière P, Mouray E, Davioud-Charvet E, Sergheraert C.
J Med Chem (2001) 44 : 1658 -1665
PubMed 11356101 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 6.59 7.41

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL294956 1 7.41
CHEMBL297528 1 7.24
CHEMBL42527 1 7.12
CHEMBL76 CHLOROQUINE 4.0 1 6.96
CHEMBL45274 1 6.88
CHEMBL46524 1 6.85
CHEMBL296488 1 6.64
CHEMBL295335 1 6.33
CHEMBL42451 1 6.22
CHEMBL294940 1 6.03
CHEMBL416068 1 6.03
CHEMBL297422 1 6.01
CHEMBL44905 1 6.00
CHEMBL296265 1 -
CHEMBL430575 1 -
CHEMBL297615 1 -
CHEMBL291186 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL294956 IC50 = 38.6 nM 7.41
CHEMBL297528 IC50 = 57.0 nM 7.24
CHEMBL42527 IC50 = 75.4 nM 7.12
CHEMBL76 CHLOROQUINE IC50 = 110.0 nM 6.96
CHEMBL45274 IC50 = 132.2 nM 6.88
CHEMBL46524 IC50 = 142.1 nM 6.85
CHEMBL296488 IC50 = 228.3 nM 6.64
CHEMBL295335 IC50 = 462.6 nM 6.33
CHEMBL42451 IC50 = 605.7 nM 6.22
CHEMBL294940 IC50 = 940.0 nM 6.03
CHEMBL416068 IC50 = 930.0 nM 6.03
CHEMBL297422 IC50 = 980.0 nM 6.01
CHEMBL44905 IC50 = 1000.0 nM 6.00
CHEMBL296265 IC50 > 1000.0 nM -
CHEMBL430575 IC50 > 1000.0 nM -
CHEMBL297615 IC50 > 1000.0 nM -
CHEMBL291186 IC50 > 1000.0 nM -