Assay Detail
Binding
CHEMBL754077
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In vitro inhibitory activity against opioid receptor in Guinea pig ileum
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis, antinociceptive activity, and opioid receptor profiles of substituted trans-3-(decahydro- and octahydro-4a-isoquinolinyl)phenols.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.31 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279968 | ETHYLKETOCYCLAZOCINE | — | 1 | 8.23 |
| CHEMBL38874 | DAMGO | — | 1 | 7.85 |
| CHEMBL152663 | — | — | 1 | 7.82 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 7.55 |
| CHEMBL150615 | — | — | 1 | 7.22 |
| CHEMBL152720 | — | — | 1 | 7.22 |
| CHEMBL153459 | — | — | 1 | 7.05 |
| CHEMBL153616 | — | — | 1 | 6.92 |
| CHEMBL347719 | — | — | 1 | 6.89 |
| CHEMBL357705 | — | — | 1 | 6.85 |
| CHEMBL153538 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279968 | ETHYLKETOCYCLAZOCINE | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL38874 | DAMGO | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL152663 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL70 | MORPHINE | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL150615 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL152720 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL153459 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL153616 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL347719 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL357705 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL153538 | — | IC50 | = | 150.0 | nM | 6.82 |