Assay Detail
Binding
CHEMBL754084
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]DADLE binding to opioid receptor
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 14-alkoxymorphinans. 2. (-)-N-(cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one, a selective mu opioid receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.40 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1254682 | LEVALLORPHAN | 4.0 | 1 | 8.59 |
| CHEMBL322796 | CYPRODIME | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1254682 | LEVALLORPHAN | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL322796 | CYPRODIME | IC50 | = | 628.0 | nM | 6.20 |