Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL754179

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity was determined against Opioid receptor delta 1 obtained from guinea pig brain membranes using [3H]naltrindole as radioligand
21
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Delta-type opioid receptor (CHEMBL236)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

8-Aminocyclazocine analogues: synthesis and structure-activity relationships.
Wentland MP, Xu G, Cioffi CL, Ye Y, Duan W, Cohen DJ, Colasurdo AM, Bidlack JM.
Bioorg Med Chem Lett (2000) 10 : 183 -187
PubMed 10673107 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 21 6.91 9.24

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL56585 CYCLAZOCINE 2.0 1 9.24
CHEMBL3085528 1 8.96
CHEMBL2367916 3 8.28
CHEMBL52399 3 7.92
CHEMBL55851 1 7.72
CHEMBL301835 2 7.27
CHEMBL56165 1 6.80
CHEMBL55392 1 6.60
CHEMBL55434 1 6.34
CHEMBL291751 1 6.33
CHEMBL293951 1 6.24
CHEMBL2021605 1 5.96
CHEMBL299114 1 5.82
CHEMBL55948 1 5.75
CHEMBL55248 1 5.55
CHEMBL543563 1 5.44

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL56585 CYCLAZOCINE Ki = 0.58 nM 9.24
CHEMBL3085528 Ki = 1.1 nM 8.96
CHEMBL2367916 Ki = 5.2 nM 8.28
CHEMBL2367916 Ki = 9.4 nM 8.03
CHEMBL52399 Ki = 12.0 nM 7.92
CHEMBL55851 Ki = 19.0 nM 7.72
CHEMBL301835 Ki = 54.0 nM 7.27
CHEMBL301835 Ki = 57.0 nM 7.24
CHEMBL52399 Ki = 110.0 nM 6.96
CHEMBL56165 Ki = 160.0 nM 6.80
CHEMBL55392 Ki = 250.0 nM 6.60
CHEMBL2367916 Ki = 270.0 nM 6.57
CHEMBL55434 Ki = 460.0 nM 6.34
CHEMBL291751 Ki = 470.0 nM 6.33
CHEMBL293951 Ki = 570.0 nM 6.24
CHEMBL52399 Ki = 920.0 nM 6.04
CHEMBL2021605 Ki = 1100.0 nM 5.96
CHEMBL299114 Ki = 1500.0 nM 5.82
CHEMBL55948 Ki = 1800.0 nM 5.75
CHEMBL55248 Ki = 2800.0 nM 5.55
CHEMBL543563 Ki = 3600.0 nM 5.44