Assay Detail
Binding
CHEMBL754180
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity was determined towards Opioid receptor delta 1 using [3H]naltrindole as radioligand
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 2: 8-formamidocyclazocine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.16 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56585 | CYCLAZOCINE | 2.0 | 1 | 8.96 |
| CHEMBL279968 | ETHYLKETOCYCLAZOCINE | — | 1 | 8.47 |
| CHEMBL58646 | — | — | 1 | 8.08 |
| CHEMBL57628 | — | — | 1 | 8.01 |
| CHEMBL60869 | — | — | 1 | 8.01 |
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 7.96 |
| CHEMBL56246 | — | — | 1 | 7.43 |
| CHEMBL299709 | — | — | 1 | 7.28 |
| CHEMBL56695 | — | — | 1 | 6.96 |
| CHEMBL298590 | — | — | 1 | 6.38 |
| CHEMBL59314 | — | — | 1 | 6.06 |
| CHEMBL56357 | — | — | 1 | 5.77 |
| CHEMBL56208 | — | — | 1 | 5.62 |
| CHEMBL293485 | — | — | 1 | 5.21 |
| CHEMBL299027 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56585 | CYCLAZOCINE | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL279968 | ETHYLKETOCYCLAZOCINE | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL58646 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL57628 | — | Ki | = | 9.8 | nM | 8.01 |
| CHEMBL60869 | — | Ki | = | 9.8 | nM | 8.01 |
| CHEMBL19019 | NALTREXONE | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL56246 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL299709 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL56695 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL298590 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL59314 | — | Ki | = | 880.0 | nM | 6.06 |
| CHEMBL56357 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL56208 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL293485 | — | Ki | = | 6200.0 | nM | 5.21 |
| CHEMBL299027 | — | Ki | > | 10000.0 | nM | - |