Assay Detail
Functional
CHEMBL754181
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration against murine P388CPT5 leukemia cell proliferation
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388CPT5 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.22 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 5.55 |
| CHEMBL3350564 | — | — | 1 | 5.12 |
| CHEMBL370100 | REBECCAMYCIN | — | 1 | 4.98 |
| CHEMBL51826 | — | — | 1 | - |
| CHEMBL52964 | — | — | 1 | - |
| CHEMBL3350565 | — | — | 1 | - |
| CHEMBL3350557 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3350564 | — | IC50 | = | 7580.0 | nM | 5.12 |
| CHEMBL370100 | REBECCAMYCIN | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL51826 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL52964 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL3350565 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3350557 | — | IC50 | > | 20000.0 | nM | - |