Assay Detail
Functional
CHEMBL754194
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Effective concentration to inhibit HIV-1 LAI cytopathicity in PBMC cells was determined in vitro
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Potent nonclassical nucleoside antiviral drugs based on the N,N-diarylformamidine concept.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 8.16 | 9.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18676 | — | — | 1 | 9.11 |
| CHEMBL18075 | — | — | 1 | 8.21 |
| CHEMBL18509 | — | — | 1 | 8.05 |
| CHEMBL278480 | — | — | 1 | 8.00 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 7.94 |
| CHEMBL418365 | — | — | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18676 | — | EC50 | = | 0.78 | nM | 9.11 |
| CHEMBL18075 | — | EC50 | = | 6.2 | nM | 8.21 |
| CHEMBL18509 | — | EC50 | = | 8.9 | nM | 8.05 |
| CHEMBL278480 | — | EC50 | = | 9.9 | nM | 8.00 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 11.6 | nM | 7.94 |
| CHEMBL418365 | — | EC50 | = | 23.7 | nM | 7.62 |