Assay Detail
Binding
CHEMBL754233
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity for Nicotinic acetylcholine receptor alpha4-beta2 in rat brain
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha4/beta2 (CHEMBL1907596) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.65 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127071 | POZANICLINE | 2.0 | 1 | 7.72 |
| CHEMBL132966 | RIVANICLINE | 2.0 | 1 | 7.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127071 | POZANICLINE | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL132966 | RIVANICLINE | Ki | = | 26.0 | nM | 7.58 |